MR Spectroscopy for Differentiating Recurrent Glioma and Postoperative Brain Radiation Injury:A Retrospective Study in China

Purpose To explore the value of MR spectroscopy(MRS) in the differential diagnosis between recurrent glioma and postoperative brain radiation injury in China. Materials and Methods The published articles were searched in CNKI database and Wanfang Data according to the diagnostic test inclusion criteria recommended by the Cochrane Collaboration Net. The heterogeneity test was taken and the pooled weighted effect size was calculated according to the corresponding effect model. The cut off values and corresponding sensitivity, specificity were also calculated. Results The pooled Cho/NAA value of recurrent glioma was higher than that of brain radiation injury(P0.05). When the cut off value of NAA/Cr was 1.01, the corresponding sensitivity and specificity were 77.8% and 55.6%, respectively. When the cut off value of Cho/Cr was 1.67, the sensitivity and specificity were 81.8% and 81.8%, respectively. When the cut off value of Cho/NAA was 2.27, the sensitivity and specificity were 85.7% and 100.0%, respectively. When the cut off value of Cho/NAA was 2.14, the sensitivity and specificity were 100.0% and 85.7%, respectively. Conclusion MRS can be used as a reliable non-invasive method to differentiate recurrent glioma and brain radiation injury, especially in terms of Cho/Cr value and Cho/NAA value.