Selective Phosphorylation of Antiviral Drugs by Vaccinia Virus Thymidine Kinase

The invention relates to a brake device for braking a movement of an object by mechanical friction, such as the movement of rails relative to a train, or the rotation of a brake disc or a cycle wheel. The brake device has a basic part with an engagement point for engagement of a braking force which can be exerted via an operator; a brake block arranged on the basic part for braking the movement of the object by friction, wherein the basic part is movable such that the brake block is movable with at least a substantial transverse component relative to the movement of the object; resetting spring means for urging the brake block away from the object to a free rest position such that in the case of a braking force smaller than the spring force a space results between the object and the brake block; a first and a second stop, which stops are arranged at a fixed mutual distance, which first stop determines the maximum distance between the object and the brake block, and which second stop adjusts itself to the contact position, i.e. the position wherein brake block and object make mutual contact, when a braking force is exerted which exceeds the spring force.