Hydroxytriamides as potent γ-secretase inhibitors

Abstract Using a cell-based assay, we have identified optimal residues and key recognition elements necessary for inhibition of γ-secretase. An ( S )-hydroxy group or 3,5-difluorophenylacetyl group at the amino terminus and N -methyltertiary amide moiety at the carboxy terminus provided potent γ-secretase inhibitors with an IC 50