Design, Synthesis, and Preliminary Immunological Studiesof MUC1-Based Antitumor Vaccines Adjuvanted with R - and S ‑FSL‑1
2020
Fibroblast stimulating lipopeptide
1 (FSL-1) is the ligand of TLR2
and TLR6 and can be used as the vaccine adjuvant to prepare antitumor
vaccines. However, FSL-1 is a stereoisomeric mixture that contains
the R stereoisomer and S stereoisomer,
and it is still unclear which stereoisomer has better adjuvant activities.
In this work, we designed and synthesized MUC1-based antitumor vaccines
adjuvanted with the stereoisomers R-FSL-1 and S-FSL-1, which were synthesized from the stereoisomeric
building blocks R-Fmoc-Pam2Cys-OH and S-Fmoc-Pam2Cys-OH, respectively. Immunological
evaluation indicated that both R-FSL-1 and S-FSL-1 can be used as adjuvants for the construction of
MUC1-based antitumor vaccines, with R-FSL-1 showing
a better adjuvant effect than S-FSL-1.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
33
References
1
Citations
NaN
KQI