The Correlation Study Between Cigarette Smoking and the Severity of Coronary Lesions in 4174 Patients With Coronary Angiography

Objective: To explore the correlation between cigarette smoking with smoking amount and the occurrence of coronary artery disease(CAD) with the severity of coronary lesions by coronary angiography(CAG).Methods: A total of 4174 patients who received CAG examination in our hospital from September 1997 to July 2001 were retrospectively studied.All patients were divided into 2 groups,Smoking group,n=1936 and Non-smoking group,n=2238,The relationship between smoking with smoking amount and CAD occurrence with the severity of coronary lesions was studied.Results: Compared with Non-smoking group,Smoking group showed younger age,higher ratios of male gender,angina pectoris,myocardial infarction(MI) and positive CAG findings,all P0.001.With adjusted multi factors,smoking increased the risk of positive CAG findings(OR=1.756,95%CI=1.54~2.01,P0.001.There 3084 patients had positive CAG results and among them,for patients with 1-vessel disease,the percentage of heavy smoking,moderate smoking and non-smoking were 39.3%,11.6% and 49.0% respectively;for patients with multi vessel disease,the percentage for heavy smoking,moderate smoking and non-smoking were 37.7%,14.7% and 47.6 respectively;P0.05.Multi logistic regression analysis indicated that elder age(≥60 years),female gender,hypertension and diabetes were the independent risk factors for patients suffering from coronary multi-vessel disease.Conclusion: In patients who received CAG examination,the positive rate was more in smokers,while the smoking amount was not related to the severity of coronary lesions.