THE ANSWER TO THE TREATMENT OF THE CHILDREN WITH GH DEFICIENCY

The aim: the evaluation of the results of the treatment with growth hormone, obtained by genetic recombination (rhGH) to a group of 47 children with pituitary dwarfism. The method: the patients have used for a year a treatment of growing advance with 0,2mg/kg/a week rhGH,( Zomacton) taken every day. We have followed: the change of the anthropometric parameters under therapy; the relation between the different parameters and the answer to the treatment. The results: during the treatment we noticed a significant improvement of the growing speed, from1,73 cm/year to 9,50 cm/year. As well as, the growing deficit has improved from -3,07 SD to -2,33 SD. To the studied group we found relations between the growing speed under treatment and the following parameters: the chronological age and the bone age at the beginning of the treatment; the delay of the bone age with more than 3 years. Conclusions: the obtained results show the fact that the treatment with rhGH to the children with pituitary dwarfism is an important ally regarding the improvement of the consequences caused by the hormone deficiency, its main purpose being the improvement of the height during the childhood and the obtaining of a final, normal height.