Synthetic pentasaccharide heparin

Pentasaccharide synthon for the preparation of synthetic heparinoids, said synthon FormulaGeneral I General Formula I (EDCBA Block) in which the configuration of the monosaccharide units and the stereochemistry of the internal junctions definecomo D-gluco-alpha- 1,4-D-glucurono-1,4-beta-D-gluco-alpha-1,4-L-idurono-beta-1,4-D-gluco, and the substituents are definencomo; X1 is selected from the group consisting of hydroxy, alkenyloxy, alkoxy, aryloxy, benzyloxy, substituted benzyloxy; alkylthio, arylthio, halogen, imidoyl, leaving groups of the phosphate ester type and related phosphate, a silyloxy tbutildifenilsililoxiu another protecting group such substituted; one lipoaminoacid or other suitable group for suconjugacion in such delivery systems or solid supports; and the stereochemistry may be alpha or beta.