Effect of metformin on PARP inhibitors-induced epithelial-mesenchymal transition and PD-L1 expression in triple-negative breast cancer.

Ye Han,Chia Wei Li

Effect of metformin on PARP inhibitors-induced epithelial-mesenchymal transition and PD-L1 expression in triple-negative breast cancer.

2019

Ye Han
Chia Wei Li

1063Background: Poly (ADP-ribose) polymerase (PARP) inhibitors have emerged as promising targeted therapies for BRCA-mutated cancers by blocking repair of DNA double-strand breaks. However, resista...

Keywords:

PD-L1
Epithelial–mesenchymal transition
Metformin
Poly ADP ribose polymerase
Cancer research
Polymerase
DNA
Pathology
Triple-negative breast cancer
Medicine
pd l1 expression

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