A comparative study of intraperitoneal ropivacaine and bupivacaine for postoperative analgesia in laparoscopic cholecystectomy: a randomized controlled trial

Introduction: Laparoscopic cholecystectomy is now the gold standard for treatment of symptomaticgallstones. After this surgery patients suffer visceral and shoulder pain secondary to peritonealinsufflation. Use of intraperitoneal and port site instillation of local anaesthetics has been used to reducepostoperative pain and decreases the need for intravenous opioids. Studies regarding comparison ofintraperitoneal use of ropivacaine and bupivacaine to reduce postoperative pain are few. This studycompared the efficacy of ropivacaine and bupivacaine in reducing postoperative pain after laparoscopiccholecystectomy.Methodology: After ethical committee’s clearance and informed consent 100 patients with symptomaticcholelithiasis, aged 20-70 years, of either gender, ASA status I to III and within ± 20% of ideal bodyweight, scheduled for laparoscopic cholecystectomy were included. . Patients were randomized into twogroups with 50 patients in each group.Group-B: Patients received 0.5% bupivacaine in a dose of 2 mg/kg diluted in normal saline to make asolution of 50 ml.Group-R: Patients received 0.75% ropivacaine in a dose of 2 mg/kg diluted in normal saline to make asolution of 50 ml.Drug was instilled intra-peritoneal through in situ placed infra-umbilical trocar before extubation. NIBP,HR, SpO2, VAS, verbal rating scale (VRS) and rescue analgesia were recorded immediately postoperativelyand then regularly every hour for the next 12 hours.Results: HR, SBP and DBP were comparatively lower in Group-R than in Group-B.The VAS score was significantly lower in Group-R from postoperative 5th hr to 12th hr. Rescue analgesiawas given when VAS was > 40. VRS score was significantly lower in Group-R from postoperative 7th hr,showing longer duration of analgesia in this group. The rescue analgesia requirement was also less inGroup-R.Conclusion: We conclude that the instillation of bupivacaine and ropivacaine intraperitonelly is aneffective method of postoperative pain relief in laparoscopic cholecystectomy. It provides good analgesiain immediate postoperative period with ropivacaine providing longer duration of analgesia.