Human exocrine pancreatic secretion changes associated with age.

: A retrospective study of data from 2352 secretin tests has been studied. Age-related changes in the structure and function of the gastrointestinal tract have been the subject of many publications. There is a consensus that basal and stimulated gastric secretion declines with age. Studies of pancreatic secretion in the elderly are scattered in the old literature and are rather controversial. Previously published data from this laboratory indicated that age and sex have little or no influence upon the secretory responses of the human pancreas to a standard dose of secretin. Almost 20 years have passed since this publication. The present report is a retrospective analysis of the observations gathered over this period.