Chemical Constituents from Sphagneticola trilobata

Objective: To study the chemical constituents of the whole plant of Sphagneticola trilobata. Methods: The compounds were isolated and purified by column chromatography and their structures were determined by spectroscopic techniques. Results: Three lignans,two indolics and two phenolic glycosides were isolated from the whole plant of Sphagneticola trilobata and identified as syringaresinol-4-O-β-D-glucopyranoside( 1),pinoresinol-4-sulfate( 2),pinoresinol-4-O-β-D-glucopyranoside( 3),1H-indole-3-carboxylic acid( 4),1H-indole-3-carbaldehyde( 5),2,6-dimethoxy-4-hydroxyphenol-1-O-β-D-glucopyranoside( 6),and 3,5-dimethoxy-4-hydroxyphenol-1-O-β-D-glucopyranoside( 7). Conclusion: Compounds 1 ~ 7 are isolated from the genus Wedelia for the first time. Compound 4 demonstrates significant inhibitory activity against α-glucosidase.