mGlu5 receptors regulate synaptic sumoylation via a transient PKC-dependent diffusional trapping of Ubc9 into spines

Sumoylation plays key roles in neurotransmission but the mechanisms regulating this post-translational system in neurons remain unclear. Here the authors show that synaptic diffusion of the sole SUMO-conjugating enzyme Ubc9 is regulated by synaptic activity via an mGlu5R-dependent signalling pathway.