Colistin efficacy in an experimental model of Acinetobacter baumannii endocarditis

ABSTRACT The in-vivo activity of colistin was evaluated in an experimental rabbit model of Acinetobacter baumannii endocarditis with a strain susceptible to colistin and intermediate to imipenem. Compared to a control group, colistin was effective (p A. baumannii from vegetations. Thus, although colistin may be effective in treating bacteraemia caused by susceptible strains of A. baumannii , it may not be a suitable treatment for endocarditis, perhaps because of poor penetration into vegetations and a low C max /MIC ratio in tissue.