miRNA and Cancer

The microRNAs are small non coding RNA which plays important role in gene regulation. Problems in miRNA biogenesis can lead to translational repression and even cancer. MicroRNAs can either act as oncogenes or as tumour suppressors. There are many factors that regulate the function of microRNAs. A network of oncogene– miRNA– Tumor Suppressor Gene (TSG) affects not only the normal cellular process but also can lead to tumourigenesis. Thus understanding the regulatory factors and the network can help to revisit the discovery process of therapeutic targets in cancer.