Amelioration of Established Diabetic Nephropathy by Combined Treatment with SMP-534 (Antifibrotic Agent) and Losartan in db/db Mice

Eiji Sugaru,Tsutomu Nakagawa,Michiko Ono-Kishino,Jun Nagamine,Teruhisa Tokunaga,Makoto Kitoh,W. Ewan Hume,Ryu Nagata,Mutsuo Taiji

Amelioration of Established Diabetic Nephropathy by Combined Treatment with SMP-534 (Antifibrotic Agent) and Losartan in db/db Mice

2006

Eiji Sugaru
Tsutomu Nakagawa
Michiko Ono-Kishino
Jun Nagamine
Teruhisa Tokunaga
Makoto Kitoh
W. Ewan Hume
Ryu Nagata
Mutsuo Taiji

Background/Aims: Diabetic nephropathy is the main cause of end-stage renal disease. Previously we have demonstrated that SMP-534 (an antifibrotic agent) prevents the development of

Keywords:

Internal medicine
Angiotensin II
Endocrinology
Losartan
Proteinuria
Diabetic nephropathy
Fibrosis
Kidney disease
Nephrology
Diabetes mellitus
Biology

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