Caspase-3 targeting: A further tile sustaining the anti-apoptotic role of miR-221 in hepatocellular carcinoma

or antiaggregants, sepsis and hemodialisys. Patients were randomly allocated either to TEG group (TEG-G), receiving fresh frozen plasma (FFP 10ml/kg) in case of R>40mm and/or platelets (PLTs 1unit/10kg) for MA 0.05). Every subject in the PPG received transfusions as compared to 6 in the TEG-G (100% vs 21.4%, p=0.000). In the PPG 15 patients (62.5%) required FFP, 5 (20.8%) PLTs, and 4 (16.6%) both PLTs and FFP. In the TEG-G none receive FFP alone, 2 needed PLTs (8%), 4 both PLTs and FFP (16%). No post-procedural bleeding or complications occurred in both groups but a transfusion-related reaction in the PPG. Survival was similar in both groups (LR p=0.78). Mean transfusion cost for the TEG-G was 188D /patient (including TEG cost), 297D /patient for the PPG (p=0.000). Conclusion: TEG is safe and effective to guide transfusion before invasive procedures reducing transfusion requirement, risk of transfusion-related side effects, and medical costs.