Assessment of quantification methods with ~(13)N-NH_3·H_2O dynamic myocardial perfusion imaging

Objective To apply 13 N-NH 3.H 2 O dynamic myocardial perfusion imaging based on myocardial perfusion models,and to quantitatively analyze the normal imaging data and then evaluate the models.Methods 13 N-NH 3.H 2 O was used as the imaging agent for PET / CT perfusion imaging.Four normal subjects were analyzed quantitatively by Duke model and Michigan model using Carimas software,and myocardial blood flow(MBF),myocardial ammonia uptake rate(k 1),myocardial ammonia washout rate(k2) and other quantitative indicators were compared.Results In Duke model global MBF and k 1 was both(0.770±0.332) ml /(g·min),k 2 was(0.219±0.253) min-1.In Michigan model,global MBF was(0.825±0.401) ml /(g·min),k 1 was(0.704±0.256) ml /(g·min),k 1 / k 2 was(3.134±0.715) ml/g.Though values of MBF and k 1 in apex of Duke model were larger than those of Michigan model,and the results assessed by two models were linearly correlative and consistent with literature reports.Conclusion For quantitative analysis of 13 N-NH 3.H 2 O dynamic myocardial perfusion imaging with PET / CT,it is necessary to choose proper model.