Distinct gene expression, mutational profile and clinical outcomes of V600E and V600K/R BRAF-mutant metastatic melanoma (MM).

Ines Esteves Domingues Pires Da Silva,Kevin Y. X. Wang,James S. Wilmott,Jeffrey Holst,John J. Park,Camelia Quek,Matthew Wongchenko,Yibing Yan,Graham J. Mann,Matteo S. Carlino,Richard Kefford,Richard A. Scolyer,Jean Yang,Georgina V. Long,Helen Rizos,Alexander M. Menzies

Distinct gene expression, mutational profile and clinical outcomes of V600E and V600K/R BRAF-mutant metastatic melanoma (MM).

2017

Ines Esteves Domingues Pires Da Silva
Kevin Y. X. Wang
James S. Wilmott
Jeffrey Holst
John J. Park
Camelia Quek
Matthew Wongchenko
Yibing Yan
Graham J. Mann
Matteo S. Carlino
Richard Kefford
Richard A. Scolyer
Jean Yang
Georgina V. Long
Helen Rizos
Alexander M. Menzies

9541Background: BRAF V600E and V600K/R mm have distinct clinicopathologic features suggesting different etiology. V600K/R mm appears less responsive to MAPK inhibitors (MAPKi) compared to V600E MM....

Keywords:

Melanoma
Gene expression
Cancer research
Pathology
Mutant
Medicine
V600E
Etiology
metastatic melanoma
MAPK Inhibitors
BRAF V600E

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