Coupling suspect and non-target analytical methods for screening organic contaminants of concern in agricultural & urban impacted waters: Optimization and application

Abstract Long-term exposure of contaminants to emerging concern (CECs) may pose risks to human health and ecosystems, even at low concentrations. Rivers impacted by both agricultural and urban activities experience distinctive environmental pressures due to receiving wastewaters that contain complex organics and their transformation products (TPs). In this study, we developed a regional database composed of 1200 CECs of high concern in Guangxi (South China). Further, we optimized a comprehensive analytical method for simultaneously screening for CECs and their TPs. The optimized screening method was applied to surface waters sampled from 10 different cross sections of a river that is impacted by both agricultural and urban activities. The best results of method optimization were achieved when the screening detection limit (SDL) ranged from 0.05 to 2 ng L−1, and over 90% of the analytes had acceptable recovery rates ranging between 64.7% and 95.6% (RSD