RDP3, A Novel Antigout Peptide Derived from WaterExtract of Rice
2020
Gout
and hyperuricemia can seriously affect the quality of life;
at present, however, existing medicines are unable to meet all clinical
needs. In the current study, a novel peptide (i.e., rice-derived-peptide-3
(RDP3), AAAAMAGPK-NH2, 785.97 Da) in water extract obtained
from shelled Oryza sativa fruits was
identified. Testing revealed that RDP3 (minimum effective concentration
100 μg/kg) did not show both hemolytic and acute toxicity, and
reduced uric acid levels in the serum of hyperuricemic mice by inhibiting
xanthine oxidase activity and decreasing urate transporter 1 expression.
RDP3 also alleviated renal injury in hyperuricemic mice by decreasing
NLRP3 inflammasome expression. Furthermore, RDP3 alleviated formalin-induced
paw pain and reduced monosodium urate crystal-induced paw swelling
and inflammatory factors in mice. Thus, this newly identified peptide
reduced uric acid levels and renal damage in hyperuricemic mice and
showed anti-inflammatory and analgesic activities, indicating the
potential of RDP3 as an antigout medicine candidate.
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