Полиморфизм гена Apo e у пациентов с метаболическим синдромом и когнитивными расстройствами

Objective. Тс determine allelic variants frequencies caused by Apo E polymorphism in patients with metabolic syndrome and cognitive dysfunction (CD). Design and methods. 54 participants had undergone anthropometric measurements, blood examination (glucose, cholesterol and triglycerides), molecular genetic analysis (polymerase chain reaction, restriction fragments length polymorphism) and neuropsychological tests. Results. Allelic variant s4 of Apo E is an unfavourable factor contributing to the development of CD, depression, anxiety disorders. Allelic variant s2 of Apo E is protective factor in relation to the development of depression.