The search for a hair-growth stimulant: new radicicol analogues as WNT-5A expression inhibitors from Pochonia chlamydosporia var. chlamydosporia

Abstract WNT-5A, a secretory glycoprotein, is related to the proliferation of dermal papilla cells. While searching for an inhibitor of WNT-5A expression, we identified an active compound, radicicol ( 1 ), and isolated four unique analogues, pochonins G–J ( 2 – 5 ), from a culture broth of the fungus Pochonia chlamydosporia TF-0480. Structural elucidation of 2 – 5 and their biological activities against WNT-5A are described.