Hierarchically Nanostructured Fe3O4/C Composite as a Promising Magnetic Targeted Drug Nanocarrier

Nanostructured Fe(3)O(4)/C composites are very attractive for high-performance magnetic targeted drug carriers. Herein, Fe(3)O(4)/C composite nanospheres with good dispersity are prepared by a simple one-step hydrothermal synthesis and subsequent heat treatment in Ar. The composite nanospheres consist of clustered primary nanoparticles, and exhibit a hierarchical architecture with a high specific surface area of 119.3 m(2) g(-1). The Fe(3)O(4)/C composite nanospheres show a high saturation magnetization value of 101 emu g(-1) and good biocompatibility. In particular, the composite nanospheres deliver a large loading content (85.8%) of epirubicin hydrochloride (EPI), resulting from their unique composition and microstructure. More importantly, the release of EPI from the EPI-loaded magnetic carrier (Fe(3)O(4)/C-EPI) may be enhanced by both a slightly acidic environment and a rotating magnetic field induced by a simple motor-driven magnet system. The above favorable properties make the hierarchical Fe(3)O(4)/C composite sample a promising candidate for magnetic targeting nanocarriers of EPI.