Method for producing a biphenyl compound

(57) Abstract: 4-Methyl-2'-, which is an important intermediate in medicine Provided is a novel method for producing a substituted biphenyl in high yield and high selectivity. SOLUTION: Using a zinc compound and an amine compound, p- Tolyl magnesium halide and o-halo-substituted benzene are reacted in an ether solvent in the presence of a nickel catalyst and / or a palladium catalyst.