Pterin Chemistry. Part 92.. Loading experiments with 6α,β-tetrahydro-L-[3′-2H1] biopterin†
1992
6α,β-Tetrahydro-L-[3′-2H1]biopterin ([3′-2H1]-1) was administered orally to two primapterinuric patients in order to investigate the biosynthetic pathway of 7-substituted pterins in humans. L-Primapterin (2) and L-biopterin were isolated from urine after loading and measured by GC/MS. L-Biopterin and L-primapterin were labelled with 2H to an equal extent. From this result, one can conclude that L-primapterin is formed from tetrahydro-L-biopterin, very probably via an intramolecular rearrangement.
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