MP09-17 WEIGHTED GLEASON GRADE GROUP (WGGG): A NEW PROSTATE CANCER BIOPSY REPORTING SYSTEM WITH PROGNOSTIC POTENTIAL

INTRODUCTION AND OBJECTIVES:Presently, prostate biopsy (PBx) results report the highest Gleason Grade Group (GGG) as a metric to gauge the overall aggressiveness of cancer and dictate treatment. Intuitively, we presumed a PBx showing multiple cores of cancer with more volume cancer per core would represent more aggressive disease. We previously proposed the Weighted Gleason Grade Group (WGGG), a novel scoring system that synthesizes all histopathologic data and cancer volume into a single numeric value representing the entire PBx, to more accurately predict adverse pathologic outcomes of radical prostatectomy (RP). This work is now extended to a second database at another institution to assess this latter potential.METHODS:We studied 171 men who underwent RP after standard multi-core PBx at a single academic institution. WGGG was calculated by summing the values of each positive core described by the formula: GGG + (GGG x % Ca/core), and normalized for a 12-core total, for a possible value ranging from 1 ...