Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues

Antonio Varone,Joanna Xylas,Kyle P. Quinn,Dimitra Pouli,Gautham V. Sridharan,Margaret E. McLaughlin-Drubin,Carlo Amadeo Alonzo,Kyongbum Lee,Karl Münger,Irene Georgakoudi

Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues

2014

Antonio Varone
Joanna Xylas
Kyle P. Quinn
Dimitra Pouli
Gautham V. Sridharan
Margaret E. McLaughlin-Drubin
Carlo Amadeo Alonzo
Kyongbum Lee
Karl Münger
Irene Georgakoudi

Fully exploiting noninvasive optical metabolic imaging systems may improve our understanding of how metabolic changes affect cancer development, diagnosis, and treatment.

Keywords:

Two-photon excitation microscopy
Glutamine
Endogeny
Cancer
Biomarker (medicine)
Fluorescence-lifetime imaging microscopy
Glycolysis
Oxidative phosphorylation
Cell biology
Biology
Metabolic pathway
Biochemistry
Bioenergetics

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