Abstract 216: Modeling Statin Hepatotoxicity with Acute Liver Specific Deletion of HmgCoA Reductase

Hmg-CoA Reductase (Hmgcr) catalyzes the conversion of Hmg-CoA to mevalonate, which is the rate-limiting step in the cholesterol biosynthetic pathway. Hmgcr is the target of statins, which are the f...