Modulation of P-glycoprotein function by amlodipine derivatives in brain microvessel endothelial cells of rats

0.05). Accumulation of intracellular Rh123 was increased and efflux of intracellular Rh123 was decreased in a time-dependent manner from 0-100 min after CJX1 and CXJ2 at 10 umol/L treatment. The inhibitory effect of CJX1 and CJX2 on P-gp function was reversible and remained even at 120 min after removal of CJX1 and CJX2 at 2.5 umol/L from the medium. Conclusion: CJX1 and CJX2 exhibited a potent effect in the inhibition of P-gp function in vitro.