VIIP: Central Nervous System (CNS) Modeling

• Several lumped CNS models exist. Our Several lumped CNS models exist . Our starting point was a mstarting point was a mo odel that had been applied to microgravity (odel todey(Pdel that had bete( g) (Stevens bees et en applied t et al., 2005; ed to mic5;5;Lakinmiccrogravityy (gnet al, 2007):•2005Time05mem e -5; L akina ete al, 2007):Timme dependent model composed of 6 fluid dedependent model ccompartments (nodes) com•partments (nopd3 vascular:3 vas•sculars:Intracranial Arteries (1)•Intracranial ArteCapillaries (2)•CapillariesVenous ariess (2)s Sinouss (3)• 2 2cVenous Sierebrospinal alal finoouso ( e luid•rebrospinaral luidVentricular CSF (4)•Ventricular CSF ( 4ExtraventricularF (4)arar CSF (6)•Extraventric1 Brain node (5)•1 Brain node (5)Boundary conditions Boundary conditions at cranium at cranium and whole le-body interaction provided by niumm and who lbody int y extracranialnodesnode•esCentral Arteries [A]•Central Arteries [A]Central Veins [V]•Central Veins [V]Thoracic Space [Y]Q = Flowrates between compartments (ml/min)C = Compartment compliance- Stevens et al. (2005)