Behavior Genetics Association 41st Annual Meeting Abstracts

with significantly increased rates of anhedonia (58%) in individuals who also experienced childhood physical abuse. While our results are highly consistent with the rodent literature, we cannot determine (as the function of rs1049353 is not well understood) whether this interaction reflects the action of the minor allele in buffering the effects of abuse on anhedonia or whether the presence of the major allele confers risk for anhedonia in the presence of abuse.