Associations of the glutathione S-transferase P1 Ile105Val genetic polymorphism with gynecological cancer susceptibility: a meta-analysis

// Erjiang Zhao 1 , Kai Hu 2 and Yan Zhao 1 1 Affiliated Tumor Hospital of Zhengzhou University, Henan Tumor Hospital, Zhengzhou, China 2 Henan Academy of Medical Sciences, Zhengzhou, Henan, China Correspondence to: Erjiang Zhao, email: // Keywords : GSTP1, polymorphism, meta-analysis, cervical cancer, endometrial cancer Received : July 02, 2016 Accepted : March 09, 2017 Published : March 31, 2017 Abstract The association between the glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism and gynecological cancer susceptibility has been evaluated in many studies. However, the results remain controversial. Thus, this meta-analysis, based on 10 published case-control studies, was designed to clarify the association of the GSTP1 Ile105Val polymorphism with gynecological cancer risk. Our results suggested that there was no significant association between the GSTP1 Ile105Val polymorphism and the risk of gynecological cancer in all genetic models (GG vs . AA: odds ratio [OR] = 1.41, 95% confidence interval [CI] = 0.75-2.26; AG vs . AA: OR = 1.13, 95% CI = 0.74-1.73; AG/GG vs . AA: OR = 1.17, 95% CI = 0.75-1.81; GG vs . AA/AG: OR = 1.38, 95% CI = 0.79-2.42). Similarly, in the subgroup analyses by cancer type, ethnicity, and smoking status, no significant association with any genetic model was observed. In conclusion, the results of our meta-analysis suggest that the GSTP1 Ile105Val polymorphism is not associated with the development of gynecological cancer.