Expanding the CRISPR Toolbox with ErCas12a in Zebrafish and Human Cells

Wesley A. Wierson,Brandon W. Simone,Zachary WareJoncas,Carla M. Mann,Jordan M. Welker,Bibekananda Kar,Michael Justin Emch,Iddo Friedberg,William A.C. Gendron,Michael A. Barry,Karl J. Clark,Drena Dobbs,Maura McGrail,Stephen C. Ekker,Jeffrey J. Essner

Expanding the CRISPR Toolbox with ErCas12a in Zebrafish and Human Cells

2019

Wesley A. Wierson
Brandon W. Simone
Zachary WareJoncas
Carla M. Mann
Jordan M. Welker
Bibekananda Kar
Michael Justin Emch
Iddo Friedberg
William A.C. Gendron
Michael A. Barry
Karl J. Clark
Drena Dobbs
Maura McGrail
Stephen C. Ekker
Jeffrey J. Essner

Abstract CRISPR and CRISPR-Cas effector proteins enable the targeting of DNA double-strand breaks to defined loci based on a variable length RNA guide specific to each effector. The guide RNAs are ...

Keywords:

Locus (genetics)
DNA
Effector
Zebrafish
Biology
Computational biology
Guide RNA
CRISPR
RNA
variable length

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