Usefulness of bull's eye quantification of ~(99)Tc~m-MIBI myocardial SPECT in patients of myocardial infarction treated with bone marrow stem cell transplantation

Objective The quantitative bull's eye analysis was used in this study to investigate the clinical value of stem cell transplantation in treating myocardial perfusion defects.Methods Sixteen pa- tients with myocardial infarction underwent rest myocardial SPECT with ~(99)Tc~m-MIBI before and after bone marrow monocytes transplantation.The changes on myocardial perfusion defects(defined as40% of the maximum activity)were quantitatively evaluated by bull's eye analysis in all cases.Results(1)The in- terpreter difference on the perfusion defect size was insignificant(t=0.52,P0.05).(2)Myocardial perfusion defect size decreased by 34.32%(t=2.83,P0.05)at 45 d,and by 14.77%(t=2.51,P 0.05)at 90 d after transplantation.The findings suggested that bone marrow monocytes transplantation could diminish the sizes of myocardial infarction,especially within 45 d.(3)Quantification of myocardial perfusion defect size was an effective index for myocardial perfusion.Conclusion Quantitative analysis of ~(99)Tc~m-MIBI-myocardial SPECT by bull's eye analysis is a reliable method in the evaluation of therapeutic effects in patients with coronary artery disease.