RAD18 transmits DNA damage signalling to elicit homologous recombination repair

Jun Huang,Michael S.Y. Huen,Hongtae Kim,Charles Chung Yun Leung,J. N. Mark Glover,Xiaochun Yu,Junjie Chen

RAD18 transmits DNA damage signalling to elicit homologous recombination repair

2009

Jun Huang
Michael S.Y. Huen
Hongtae Kim
Charles Chung Yun Leung
J. N. Mark Glover
Xiaochun Yu
Junjie Chen

The ubquitin ligase Rad18 is a central mediator of cell cycle checkpoint activation by DNA damage. Now Rad18 turns out to directly regulate homologous recombination repair by interacting with Rad51C

Keywords:

Cell biology
CHEK1
DNA repair
DNA ligase
G2-M DNA damage checkpoint
Molecular biology
Homologous recombination
Replication protein A
DNA damage
Gene conversion
Biology

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