Histopathology of Childhood Pneumonia in Developing Countries

Acute lower respiratory infection in children is a major cause of morbidity and mortality in developing countries. Viral and bacterial agents incite characteristic host responses at the level of the bronchi, bronchioles, alveolar walls, and air spaces that correlate with the clinival course. A systematic review of histopathologic features will enhance the understanding of the pathogenetic mechanisms and cofactors that influence the disease process, particularly how tissue injury may be influenced by nutritional status and acccess to antibiotics. Research priorities include immunologic assessment, micronutrient assays, and standardized autopsies in developing countries