Drug-induced hepatotoxicity

Abstract The liver is the largest gland in the human body and it is situated in the right side of the upper abdominal cavity. Liver damage can be generally caused by drugs, particularly antitubercular, paracetamol, general anesthetics, and some anticancer drugs. Toxic hepatitis is the most common severe adverse reaction caused by antituberculosis drugs. It mostly starts in the first few weeks of treatment accompanying liver necrosis, which may unfold to neurological disorder and death. Apart from synthetic drugs, many agents such as alcohol consumption also play a significant role in liver damage. Although many synthetic drugs are available to treat hepatotoxicity, still natural product-based drugs such as silymarin are among the favorable choices for hepatotoxicity.