Highly Potent Analogs of Human Parathyroid Hormone and Human Parathyroid Hormone-Related Protein

It is well established that intermittently administered human parathyroid hormone, hPTH(1–84), and its fragment hPTH(1–34) effectively increase bone mass in animals and humans. Because of its unique bone anabolic effect, PTH is considered a potential therapeutic agent for the treatment of osteoporosis. However, the native hPTH(l-84) and its fragment hPTH(l-34) have a relatively narrow therapeutic index, above which they can cause bone resorption and hypercalcemia. To address this problem, we have designed and identified novel PTH/PTHrP analogs that have a wider therapeutic index.