Effect of Zoledronic Acid Combing with Radio Frenquency Hyperthermia on Managing Bone Metastasis Tumor

To reveal the effect of bisphophonates combing with radio frenquency(RF) hypertheramia on management of bone metastasis tumor.48 cases of bone metastasis tumor were divided into two groups,25 cases were treated with zoledronic acid alone and 23 cases by zoledronic acid with RF hyperthermia. All cases were injected with zoledronic acid, a type of bisphophonates, then 23 patients received RF hyperthermia. The pain score was detected by visual analogues score(VRS), and CT,MRI or single photon emission computed tomography(SPECT) were applied to evaluate the bone lesion.The results showed that in bisphophonates and RF hyperthermia group,6 cases were complete relaxation(CR), 5 cases were relaxition (PR),8 cases were stable(SD),the control rate of disease was 82.6%, 6 cases were observed bone lesion decreased(26.1%);2 case were CR,5 cases were PR and 6 cases were SD in bisphophonates group,control rate of disease was 52.0%(P0.05),7 cases with lesion decreased 〔28.0%(P0.05)〕. No serious adverse effect was found in the two groups.It concludes that biophosphate plus RF hyperthermia is a more effective way to manage pain and lesion in bone metastasis than bisphophonates alone.