Avoiding H/D Scrambling with Minimal Ion Transmission Loss for HDX-MS/MS-ETD Analysis on a High-Resolution Q-TOF Mass Spectrometer.

Daniel T. Weltz Wollenberg,Stuart Pengelley,Jeppe Christian Mouritsen,Detlev Suckau,Christian Isak Jørgensen,Thomas J. D. Jørgensen

Avoiding H/D Scrambling with Minimal Ion Transmission Loss for HDX-MS/MS-ETD Analysis on a High-Resolution Q-TOF Mass Spectrometer.

2020

Daniel T. Weltz Wollenberg
Stuart Pengelley
Jeppe Christian Mouritsen
Detlev Suckau
Christian Isak Jørgensen
Thomas J. D. Jørgensen

Hydrogen/deuterium exchange monitored by mass spectrometry (HDX-MS) enables the study of protein dynamics by measuring the time-resolved deuterium incorporation into a protein incubated in D2O. Usi...

Keywords:

Hydrogen–deuterium exchange
Hydrogen
Mass spectrometry
Scrambling
Chromatography
Protein dynamics
Deuterium
Ion
Analytical chemistry
Transmission loss
Chemistry

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