Development and validation of spectroscopic method for estimation of valacyclovir in tablet dosage form

1. It is chemically 2-[(2-amino-6-oxo-3, 9-dihydropurin-9yl) methyxy] ethyl-2-amino-3-methylbutanoate 2 . It is an antiviral drug used in the treatment of herpes simplex and herpes zoster. It inhibits viral DNA synthesis 3-6 . It is prodrug intended to increase the bioavailability of acyclovir by increasing lipophilicity, valacyclovir converted by esterase to active drug acyclovir via hepatic first pass metabolism. Extensive literature survey reveals that only HPLC and LC-MS method for the determination of Valacyclovir in plasma samples has been reported 79 . So, in the present work, an attempt as being made to develop simple UV-spectrophotometric method for estimation of the drug in tablet dosage form.