Topical and systemic Ofloxacin (Tarivid) in the treatment of Gentamycin-resistant Pseudomonas corneal abscess

The authors present a case of fulminant, devastating Pseudomonas corneal abscess associated with hypopion and extensive stromal infiltrates. In spite of massive intravenous, sub-conjunctival and topical Cefazolin and Gentamycin administration, there was a continuously worsening course with early formation of descematocele and a threat to the integrity of the eye.Based on previous reports in the literature on the efficacy of I.V and topical Ofloxacin (Tarivid) treatment of Gentamycin-resistant Pseudomonas keratitis in vitro and in vivo, intravenous 200 mgx2/day Ofloxacin as well as hourly topical Ofloxacin 0.3% was administered. Dramatic and significant improvement was gradually observed with complete resolution of the corneal infiltrates and scarring of the descematocele as well as healing of the epithelial defects within 14 days. No local side effects were observed. The authors recommend topical and systemic Ofloxacin treatment in Gentamycin-resistant Pseudomonas corneal ulcers.