Association between lung function and airway wall density
2009
Computed tomography (CT) examination is often used to quantify the relation between lung function and airway
remodeling in chronic obstructive pulmonary disease (COPD). In this preliminary study, we examined the
association between lung function and airway wall computed attenuation ("density") in 200 COPD screening
subjects. Percent predicted FVC (FVC%), percent predicted FEV1 (FEV1%), and the ratio of FEV1 to FVC as a
percentage (FEV1/FVC%) were measured post-bronchodilator. The apical bronchus of the right upper lobe was
manually selected from CT examinations for evaluation. Total airway area, lumen area, wall area, lumen perimeter
and wall area as fraction of the total airway area were computed. Mean HU (meanHU) and maximum HU (maxHU)
values were computed across pixels assigned membership in the wall and with a HU value greater than -550. The
Pearson correlation coefficients (PCC) between FVC%, FEV1%, and FEV1/FVC% and meanHU were -0.221 (p =
0.002), -0.175 (p = 0.014), and -0.110 (p = 0.123), respectively. The PCCs for maxHU were only significant for
FVC%. The correlations between lung function and the airway morphometry parameters were slightly stronger
compared to airway wall density. MeanHU was significantly correlated with wall area (PCC = 0.720), airway area
(0.498) and wall area percent (0.611). This preliminary work demonstrates that airway wall density is associated
with lung function. Although the correlations in our study were weaker than a recent study, airway wall density
initially appears to be an important parameter in quantitative CT analysis of COPD.
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