Emulsified Isoflurane Enhances Thermal Transient Receptor Potential Vanilloid-1 Channel Activation-mediated Sensory/Nociceptive Blockade by QX-314

Background:QX-314 produces nociceptive blockade, facilitated by permeation through transient receptor potential vanilloid-1 (TRPV1) channels. TRPV1 channel can be activated by noxious heat and sensitized by volatile anesthetics. The authors hypothesized that emulsified isoflurane (EI) could enhance