The hypertrophied myocardium and coronary disease. Structural changes in patients submitted to aortocoronary bypass surgery

Abstract Seventeen patients with coronary disease submitted to myocardial revascularization were studied. Ten patients had a hypertrophied ventricle, and 7 had normal ventricular mass. Myocardial biopsies were obtained before ischemia and at the time of reperfusion and were assessed for: volume fraction of fibrous tissue, myocyte diameter, morphometric mitochondrial studies and ultrastructural changes. The volume fraction of fibrous tissue in patients with hypertrophied ventricle was 1.9 ± 0.04, and in patients with normal ventricular mass was 0.9 ± 0.01 ( p p p