Razón ApoB/ApoA-1, grosor de íntima media y su posible relación.

La razon ApoB/ApoA-1 y el grosor de intima media son marcadores de aterosclerosis y riesgo cardiovascular. Proposito: Determinar la razon ApoB/ApoA-1, grosor de intima media y su posible relacion en la poblacion del Area de Salud ¨Heroes del Moncada¨ 2011-2013. Material y metodo: Estudio observacional, transversal, descriptivo. Universo: 1004 individuos de 40 a 70 anos. M uestra: 146 personas. Variables: ApoB/ApoA-1, g rosor de intima media. Analisis estadistico: Como medidas de resumen para variables cualitativas se utilizaron frecuencias absolutas, porcentajes y para las cuantitativas medias, desviaciones estandares, errores estandares, medianas, cuartil 1 y 3. Comparacion de medias: WILCOXON y KRUSKAL-WALLIS. Se realizo regresion lineal multiple. Se ajustaron modelos de regresion logistica. Se fijo nivel de significacion del 95%, p< 0.05. Resultados: Las medianas de la razon ApoB/ApoA-1 fueron mayor en hombres y se incrementaron con la edad. Las medianas del Grosor de intima media fueron mayores en hombres y se incrementaron con la edad. A medida que aumenta la edad y la razon ApoB/ApoA-1, se incremento el grosor de intima media. Conclusiones: La relacion entre estos marcadores de riesgo cardiovascular fue significativa. Palabras clave: tumores cardiacos primarios. ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ABSTRACT The ApoB/ApoA-1 ratio and the carotid intima media thickness are markers of atherosclerosis and cardiovascular risk. Objective: To determinate the ApoB/ApoA-1 ratio, the carotid intima media thickness and its possible relationship in the health area ¨Heroes del Moncada¨ population 2011-2013. Method: Descriptive transversal and observational study. Sample amount: 1004 individuals frame 40-70 years: Sample: 146 persons. Variables: ApoB/ApoA-1, carotid intima media thickness, age, sex, smoking, hypertension, obesity, triglycerides. Statistical analysis: As summary measures for qualitative variables there were used absolute frequencies, percent, and for the quantitative there used mean, standard deviations, standard errors, median, quartiles 1 and 3. It was also used a mean comparison: WILCOXON y KRUSKAL WALLIS. It was done a multiple lineal regression. There were adjusted the models of logistic regression. It was established a level of significance of 95%, p< 0.05.Results: The median of the ApoB/ApoA-1 ratio were bigger in men and they were higher depending on higher ages. The median of the carotid intima media thickness were bigger in men and they were higher depending on higher ages. As age goes up and the ApoB/ApoA-1 ratio, the carotid intima media thickness goes up too. Conclusions: The relationship among these cardiovascular risk markers was significant. Key words: apolipoproteins, carotid intima-media thickness, atherosclerosis .