Fatty Acid Synthase Inhibitors from Geum japonicum Thunb. var. chinense

) Epithelial Cell Biology Research Centre, The Chinese University of Hong Kong, Hong Kong,P. R. ChinaBioassay-guided fractionation of the MeOH extract of Geum japonicumThunb. var. chinense usingthe fatty acid synthase inhibition assay led to the isolation of a new dimeric ellagitannin, gemin G (1),together with six known compounds, gemin A (2), casuarinin (3), pedunculagin (4), potentillin (5),tellimagrandinII(6), andellagicacid(7).Theirstructuresweredeterminedonthebasisofspectroscopicanalyses. Compounds 1–7 displayed strong inhibitory activities on fatty acid synthase with IC