Landscape of GATA3 mutations identified from circulating tumor DNA clinical testing and their impact on disease outcomes in estrogen receptor-positive (ER+) metastatic breast cancers treated with endocrine therapies.

Marko Velimirovic,Lorenzo Gerratana,Andrew A. Davis,Charles Sichao Dai,Ju Cheng,A. John Iafrate,Bruce A. Chabner,Massimo Cristofanilli,Aditya Bardia

Landscape of GATA3 mutations identified from circulating tumor DNA clinical testing and their impact on disease outcomes in estrogen receptor-positive (ER+) metastatic breast cancers treated with endocrine therapies.

2021

Marko Velimirovic
Lorenzo Gerratana
Andrew A. Davis
Charles Sichao Dai
Ju Cheng
A. John Iafrate
Bruce A. Chabner
Massimo Cristofanilli
Aditya Bardia

1065Background: The GATA3 gene encodes for a transcription factor (TF) that plays a pivotal role in the development of breast tissue. Breast tumors with lower GATA3 expression have worse prognosis ...

Keywords:

Cancer research
Endocrine system
Circulating tumor DNA
Medicine
Estrogen receptor
Gene
Transcription factor
GATA3
disease outcome
metastatic breast

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