A phase I clinical trial of the effect of belinostat on the pharmacokinetics and pharmacodynamics of warfarin
2016
Purpose
Belinostat is a potent small molecule inhibitor that exerts its antitumor effect through inhibition of histone deacetylase. The purpose of this study was to evaluate the pharmacokinetics and pharmacodynamics of warfarin (as a reference drug metabolized by CYP2C9) in the presence and absence of belinostat.
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