One-Pot Decarboxylative Acylation of N-, O-, S-Nucleophiles and Peptides with 2,2-Disubstituted Malonic Acids.

Carbonyl benzotriazoles, generated from 2,2-disubstituted malonic acids and benzotriazole, readily acylate nucleophilic reagents and peptides furnishing libraries of conjugates and peptidomimetics.